When I retired in the 80's I picked up a Baretta 21A. I carried a lot for 15 years. It was nice looking and grip size for that little .22 was perfect. It was very light and a pleasure to carry. The only problem with it was that it wasn't dependable enough for carry. It was fine for plinking at cans, or targets, but too undependable for self defense. I should've known better with my experience in LE to not have carried it after seeing it fail to fire on a number of occasions. That was a very big mistake and not smart on my part.
It always functioned well with Federal high velocity ammo, but I always had the concern in the back of my mind that it would fail when I needed it most. In addition that gun hasn't any extractor to remove the shell casing and during an emergency if the round doesn't go off you just don't have the time to put something through the barrel to poke it out.
The .22 is the most unreliable calibre there is and the added disadvantage of not being able to eject a bad round just makes it almost suicidal to carry in the role of a defense weapon unless perhaps you're carrying it as a backup. I stepped up to the NAA .32 loaded with Federal Hydra Shok ammo ten years ago with no failure to feed, or fire anything I put through it. It is larger and heavier than the Baretta was, but it's still small and what's more important it's been very dependable so far. In addition that round can definately cause damage.