Current doctrine in the U.S. is Condition 1 carry. I recommend a quality holster that will keep the trigger from being pushed and keep the gun from falling and being grabbed in midair . Never " depend " on a safety .
The Israelis carry in Condition 3 for their own reasons, the main one being that they issue a wide variety of pistols and all operate the same from Condition 3 . That allows a person to carry an M-9 one day and a BHP the next without retraining .