If I was going to carry a CZ. It would probably be the P01 or the P07 given a choice.
That said, aside from size (and that's not really a big deal), I can't think of any reason not to carry a full sized CZ75. It's similar in size to a 1911, though a bit thicker in the grip. I don't find them to be particularly heavy, of course opinions vary. Concealment may not be especially easy, but it's certainly workable with a bit of thought. People conceal full sized 1911s all the time. A CZ75 can't really be that much harder.
As for action type and manipulation of the controls, Mine is a CZ75BD (decocker) so it's pretty darned simple. The standard style safety is not a big deal. What ever you carry, practice with it so that it becomes second nature.
MSgt, USAF, Retired
NRA Life Member
The hardest thing to explain is the glaringly evident which everybody had decided not to see. - Ayn Rand