I guess I would begin by telling you! If you will not carry it frequently there is an issue. To explain. First of all I am not a 380 fan however I carry a Kahr P-380 in the heat of the summer or with light clothing when anything larger would be harder to hide. Other times I carry my Model 27 Glock or my Colt 1911 Commander. Bottom line the weapon will do you no good in the glove box of your vehicle. So carrying a smaller cal is better for those times if you would carry it everywhere each day.
I can understand about a full size pistol. The likelihood of a confrontation will come vary rarely while you are setting in your vehicle. It will come unexpectedly when shopping, pumping gas, or just general chores. Also comfort of the holster is also important. I carry a DeSantis Ankle holster in hot weather when it is difficult to hide a larger pistol and then carry the Kahr P-380. So a good compact might be what you need. But keep both if you can! One can never have enough weapons!