The only real concern about buying a Python is the inflated price. You can have a SW or a Ruger GP100 (I did) that will hit targets about as well.
The Colt timing problems are greatly exagerrated, like Mark Twain's premature death. First, the DA Colts are not all the same. The Python stands apart, because it has an additional cylinder stop, resulting in the bank vault locking. Try it with an Anaconda or other newer models. You will see a normal cylinder shake.
The Python has been compared to a fine sports car. You don't beat it up like a pickup truck. It may be higher maintenance. Even if you do, the hand was designed to be replaceable. (Admittedly a moot point today) I've had two, bought used, keeping one, used to shoot both a lot, never a timing issue. Grant Cunningham has recently published a book on revolvers, he is totally consistent on this. For some reason, the "bad timing" rumor keeps getting undue attention. Maybe it is comforting as an excuse not to pursue a Colt, but even then it is redundant. The prices are so high, I'd think again before buying a Python today. Definitely not an Anaconda or a King Cobra for this kind of money.