To withstand the varying pressures involved in the various rounds, the revolver is made with mil spec 4330 modified vanadium steel (the same alloy used in the Gatling gun barrels of F-16 Falcon fighters) and is specially hardened.
I still think the Medusa could do it, If the chamber was long enough....

Sounds to me like no revolver could shoot this bullet... It even cuts the top strap on revolvers built for this cartridge. I read the manufactures of these guns DONT want you shooting the .357 Max outta them anymore.
Seems the only guns that can handle this cartridge are single shot.....