First off, the previous poster said what is most important...practice, then choosing a load that hits where you want it, like Hornady Leverevolution 225 grain FTX, and sighting in at 50 yards. If you are not a practiced hand gun hunter, I would not go beyond 50 yards to attempt a kill shot, but that is just me. Now as far as a scope, remember this..The recoil velocity of magnum handguns is much higher than that of ordinary hunting rifles, and this subjects the internal parts of an optical sight to great stress every time the gun is fired. On a .22 rimfire or a standard centerfire caliber like the .38 Special a lower priced optical sight may be satisfactory (I have had mixed results with Tasco red dot sights, for example), but on a magnum revolver it simply makes sense to buy the very best you can afford. Weaver, Leupold, and Nikon are three great scope makers and I would look into one of theirs specifically made for high powered handguns. Good luck with what ever you choose..try Optics Planet for good pricing. And remember this is only my opinion, I am no expert, with only 45 plus years using handguns for hunting, plinking and the like.