Just as a follow up. Got this from a guy on the Great Western Collector's forum: No worries….I think most fellows do learn this the first time they buy an Uberti. It comes up often.
This is called the “swiss-safe” safety because it was first used on the Swiss Hammerli single-action. The drop test was mandated in about 1970 as an import requirement, and this has been the favored way to get imported single-actions to pass the drop test without changing the mechanical nature of the traditional single action. Heritage are made in Florida, so they are not bound by that rule.
So what you do is exactly that. Depress the cylinder pin button screw and pull the pin out until it clicks.
I have one of those $250 Hombres, and that is an extremely good value.