Many women love the lightweight 13 1/2-oz. Ruger LCR and its sweet double-action trigger. Adding a Crimson Trace Laser to it will give the ladies even more confidence.
As for ammo, keep in mind that recoil is a major issue with women, so have them practice with the easy-going 148-gr. wadcutters first.
In my LCR, the short barrel STANDARD PRESSURE 158-gr. LSWCHP from Buffalo Bore shot to Point of Aim at 21' and had the LOWEST recoil of 7 brands of self-defense ammo, with Speer's 135-gr. Gold Dot load having the most / snappiest recoil. If in open areas where overpenetration isn't a concern at all, a hardcast wadcutter might be preferred:
Buffalo Bore Short Barrel:
** 158-gr. Standard Pressure
Lead Semi-Wadcutter HP (20C) @ 854 fps in 2” barrel. Less recoil & similar velocity as Speer’s 135-gr. Gold Dot @ 860 fps.
Buffalo Bore Short Barrel Low Flash 158-gr. FBI Load
* 150-gr. Standard Pressure
Hardcast Wadcutter (20D) @ 868 fps in 2” barrel.
Buffalo Bore Short Barrel 150-gr. Hardcast Wadcutter