Based on my limited experience with the Smith and Wesson 460, I would say if you have the money go ahead and get it. One of the big reasons I say this is, because the 460 can fire the .460 S&W cartridge, the .454 Cassull, .45 Colt, and .45 Schofield.
"It's a gun you loaded on Sunday, and shot all week."
"If God didn't create man equal then Sam Colt had made them equal."
"Fast is fine, but accuracy is everything."