If I ever buy another revolver for hunting it will be a .460 S&W. That is about the most practical choice today. You have full house .460's for big game, .454Casual for big/medium game and .45 colts for cheap fun. What more could you ask for?
I guess I'm old school again, as I still Like a simple 357 Magnum coupled with a 6" barrel and a good set of rubber grips! It shoots well, it hits well and Nope, not the most easy to carry, but will usually end a gunfight in short order! Plus, you can shoot less expensive 38 SPCL in it and do no harm!
I'll be the oddball. .41 mag. Does what the .44 does with flatter trajectory and less (percieved) recoil. 170 JHC @1600 fps to 210 SWC GC at 900. The only problem is availability of components. I have been shooting the .41 for long enough that I have plenty of cases (1000) and I cast my own bullets. When I see jacketed bullets being closed out at reduced prices I buy all they have.