I shot a 4" Python for 5 years and it was smoother than my SW 686. Accuracy was on par w my SW 6". I regret parting w it but my gunsmith said the close tolerances and heavy recoil require them to be rebuilt and the work wasn't easy. Everyone has regrets...But the SW is still running strong and w trigger job is just as smooth.
Not all Pythons were created equal. Some parts required hand fitting and skilled labor. People retire and it takes time to replace & train new people but Colt didn't lower their prices in the process. This was another reason they fell out of favor.
The adage, "Everything old is new again," certainly holds true for Pythons as they are now a status symbol like expensive jewelry & Rolex watches. In good condition, $1,500 to $2,500 is not out of line. The 3" barrel model sells at a premium.