I had a Colt Python some years ago, and was surprised that it wouldn't take my handloads using the 173 gr. cast bullet, the cylinder being a tad too short. But then, neither would the S&W .357 Magnum (later dubbed the Model 27). Both the Ruger Blackhawk and Smith Model 19 did.
But when Smith introduced the Model 586 and I got my hands on that, I left the Python behind. I still consider the Model 586 L-Framed gun the finest .357 DA Revolver to come on the market. It is far more rugged than the Python, and Smith's DA was always far away better than Colt's.