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I just bought one in .357, it's a ton of fun. I went .357 because of ammo costs and I already had dies for .357. I also like the option of shooting .38 Special out it. I know .45 Colt is the traditional caliber, but I want the flexibility of .357. You can't go wrong with either one.
45 LC can be loaded to 357 specs and damn near 44 mag specs. or loaded very light like a 38 special. The 45 colt caliber coupled with a Ruger is one of the most versatile calibers out there.
.45 Colt's only problem is the brass is thinner than a .44Rem mag, so full house loads tend to lengthen the brass significantly, if you're doing a lot of them, it's a pain trimming and the case life is shorter