Location: Third bunker on the right,Central Virginia
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Sure! Just replace the cylinder, And cylinder latch, And the hand. And the hammer/ firing pin. But that won't fit in the frame, so you replace the frame. And the barrel, And the sights are off, so replace those.
But the grips should fit just fine.
What we have here is... failure- to communicate.
It's probably cost prohibitive now, but years ago I saw a few revolvers rechambered to smaller caliber by sleeving the chambers and bore. This was very popular with the Webley Royal Irish Constabulary (RIC) models which were .442 caliber. I saw a few chambered for .25-20 WCF in this manner, and selling for $12 ~$15. The Webley Mk IV were going for $14.95 at that time.
And some Colts were rechambered from .38 S&W to .22 L.R. in the same manner, with changing out the firing pin, of course.
I never shot one of the .25-20s, but wondered at the practical use of a snub .25-20!
Waaaaay impractical, but illustrates anything can be done.