This is a personal thing, I doubt this applies to everyone: It's hard for me to not relax my wrist to early with the Bisley grip. I have no problem with the Blackhawk or a mono-grip.
"I do not aim with my hand; I aim with my eye. He who aims with his hand has forgotten the face of his father.
I do not shoot with my hand; I shoot with my mind. He who shoots with his hand has forgotten the face of his father.
I do not kill with my gun; I kill with my heart. He who kills with his gun has forgotten the face of his father."
The Bisley grip put my hand in an awkward position relative to the line of sight. It kinda made me have to forcibly bend my wrist downward to aim the gun. Then the recoil went more straight to the rear, rather than the normal way a SA revolver swings upward. So now I only have the standard SAA/Blackhawk/Vaquero grips on my SA revolvers.