Lots of good choices, and people have preferences -- there are Smith guys, Colt guys, Ruger guys......
I recommend you find a way to take a few shots (borrow, rent) one each of the following:
Smith J-frame, K-frame, L-frame -- Ruger GP100 and SP101 -- Colt if you can, Colt revolvers are getting harder to find all the time.
I have a S&W model 19 and a Python. I love them both, but if I was forced to choose I'd go with S&W. However I know a lot of Ruger lovers.