It's all about cartridge selection.
As stated previously, 10 mm ticks a lot of the right boxes. Guns for it are pretty easy to find. Glock, various 1911s and the EAA Witness pistols. If you want to up it a notch, check out the .460 Rowland.
Have your cake & eat it too.
MSgt, USAF, Retired
NRA Life Member
The hardest thing to explain is the glaringly evident which everybody had decided not to see. - Ayn Rand