My wife is 5'1" and she has tiny hands and she can both work the action and fire my 1911 .45. So I think the size factor of a 1911 should be taken off the table at least until she's shot one. The SIG or GSG 1911-22's are great pistols she should give one a try.
One the other end of that argument, Browning makes a 1911-22 that is 80% the size of a full size 1911. Which makes it about the size of a Ruger SR22 or that Walther P22. It's a very unique pistol and very true to the original JMB design.
SIG 1911 .45 ACP
SIG P229R 9mm
Beretta BU9 Nano 9mm
Beretta 84FS .380 ACP
Ruger MKIII 22/45 Target .22LR
PWS (Primary Weapons Systems) MK114 5.56