I've heard nothing but good things about the critical defense rounds but personally I had no interest in the 45 flavor. I personally like 230gr bullets and there are so many good options out there in 45. I think they show their performance better in the smaller calibers such as 38 or 380 but that's just my opinion.
If your weapon shoots them well and you feel comfortable with them, go for it.
If the pain is lacking so is the discipline...
"the only 911 call I need is chambering a round" - Mr. Muller, MO car dealer