Best .22 handgun
You didn't state what purposes it's going to be used for so I'll assume you will be plinking,small game hunting,and perhaps target shooting. I'll be first to reccomend the excellent ruger mk 2 or mk 3 semiauto target pistols. There's others available but I honestly feel it's the best. You can get truckloads of upgrades and parts for them. I have a slab side competition that I've extensivily modified and it'll group 1/2" at 50 yards from STEADY rest!!!