The full length 10MM (not 40S&W) is about as powerful as a 41 magnum. The 357 SIG (which I have and really like) is made to equal the 357 magnum with 124/125 grain bullets. Different animals. For self protection, I'd go with the 357, for hunting, the 10MM.
"An unarmed man can only flee from evil, but evil is not overcome by fleeing from it"