Unfortunately a friend of mine lost his life to a single shot from an "anemic" 25auto, so I chose to learn from that lesson and will treat any firearm and cartridge as deadly regardless of popular belief. Also by design a centerfire will always be more durable/reliable than a rimfire. I rarely see centerfire cartridges with primer strikes at the range but there are always 22LR's with one, two, or three strikes and or a damaged bullet left behind. I wouldn't trust my life to a 22 or 25 but they sure are fun to shoot.
"THE CONSTITUTION ONLY GIVES PEOPLE THE RIGHT TO PURSUE HAPPINESS, YOU HAVE TO CATCH IT YOURSELF." ~BENJAMIN FRANKLIN.