You're going to have a hundred different opinions, all the way from Walther P22's to the Beretta Neos to the M&P 22 to the GSG 1911 in .22lr. They're all fine. They shoot. Some people will suggest high-end S&W 41A, but they're a thousand bucks.
But in the end it is still going to come down to the same answer it does in every other .22lr pistol thread.
Ruger Mark II, Mark III or 22/45 or Browning Buck Mark. Starts around $300. Nicely equipped at $500. Infinitely customizable and upgradable.
There ya go. All distilled down to the nitty gritty.
I went Buck Mark. I can share mags between my two. Let's see the Ruger guys do that!
Oh yeah, they're worthwhile. They're fun and the ammo is cheap.