Both would do a good job but yeah 8 to 12 .33 pellets would be a lot more devastating than a single .45 hit. Right now though I'd still grab my .45 as I have a lot more training with it and I have a light mounted on it (X-300), keeps one hand free to open doors etc.
Remember this when you support the labeling and tracking of people and the complete digital takeover of commerce:
"It causes all, both small and great, both rich and poor, both free and slave, to be marked on the right hand of the forehead so that no one can buy or sell unless he has the mark, that is, the name of the beast or the number of its name" Revelations
"So you say your prayers and you thank the lord, for that peace maker in the dresser drawer"