I don't wanna be shot with any caliber! not even a 22lr!
.....but if we are pretending here that I am a cop...... then I choose my situation to be - Perp shooting at me while I am taking cover behind the door of my cruiser. I choose for him to be using a .45 auto 1911 with hollow points. The bullets after penetrating the door of the cruiser will have expanded and bled off a lot of energy and thus will not inflict as much pain since I am obviously wearing my vest. after he runs through his 7-8 round mag, I step from behind cover and dispatch him with my sidearm.
"No free man shall ever be debarred the use of arms. The strongest reason for the people to retain the right to keep and bear arms is, as a last resort, to protect themselves against tyranny in government"
-- Thomas Jefferson, 1 Thomas Jefferson Papers, 334