I recommend 10mm for anyone who likes high power handguns. I shot .357 mags, .40 S&W and .45 Auto for years and still do. Then a few years ago I saw a S&W 1006 sitting behind the glass at a local shop for $399 and had to have it. I've never been upset with its performance and enjoy shooting my 10mm's as much as any hangun I own.
It's a good strong accurate round and I don't see it going anywhere for a long time to come.
As far as ammo goes, during the shortage I picked up 600 rounds of HSM for $14.95 a box and now it's readily available on the shelves locally for the same price I pay for .357 mag & .45 FMJ, so it hasn't been an issue for me.
My 1076 seems to like the Cor-Bon ammo fairly well.