If we are talking soley handguns I have two, one of them are always in arms reach.
First is my Springfield XDM40 3.8" with a tlr-4
Second is my Ruger SP101 4.25"
Aside from just handguns I also always have my Remington 870 express tactical 12ga pretty close.
All three loaded with hornady critical defense
Cz 82 with hornady critical defense ammo!! Love that gun.
My mossberg 500 i keep Winchester fragmenting hollow points PDX slugs and some 00 buck shot on the side saddle
I have a lot of trouble w/ snakes and stray dogs so my go to gun is a Ruger 22/45. I'll make it work as a PDW if it becomes necessary.
Me, Glock 21
Wife, XDM 9mm
The dog is on his own
My pet black panther. MEOW!!