That's a pretty tough question, but I reckon after all is said and done, I'd have to pick this Ruger:
It's a New Model Super Blackhawk, case colored by Doug Turnbull, rosewood grips by Lett, and a Millett Rear sight.
Or it might be this one, which is with me daily:
It's an old Three Screw .357 Magnum Blackhawk, converted to .44 Special by Dave Clements, case colored by Doug Turnbull, walnut grips by CaryC.
This one is my daily carry gun.