I carry 22LR around my yard when I'm in the copperhead zone. All other times, I carry, .38, .357, .380, .40, and 9mm. I practice regular from the draw and hit my targets effectively. Whenever I am carrying one of those calibers, it is the smallest I have at the time and I trust all of them. More people are killed by .22 than any other caliber BTW.
Yea though I walk through the valley of the shadow of death, I will fear no evil. My rod is a GLOCK and it comforts me