Depends on the size of your hands and if you prefer revolver or semi-auto.
Small, light weight revolver - Ruger LCR
Small, relatively light weight Semi - Kimber Ultra Carry. You can get that in 9mm or .45ACP
Small, solid semi - Kahr K-9 or K-40
Larger SA/DA - Sig P220 Compact
Full Size 1911 - Kimber, any flavor that turns your crank
Full Size SA/DA - Sig P220 (with or without rail)
These are all "set it up and forget it" guns (does require a cleaning once or twice per year to keep lint/dust to a minimum). One key word - reliable!