I also own and love the ruger 22/45. Yes, you have to make sure that mag is slapped home so the first round feeds, and yes, it is a BITCH KITTY breaking down this thing--at first. Once you break it in though, it comes apart and functions much smoother....
Funny thing though, when Im using it at the range and old-timers see it, they more often than not tell me "eh, you dont have to break down those things--theyre made to take a beating". One fella told me he just dumps some kerosene down the barrel every so often, then oils it.
When I do shoot mine, I shoot it a LOT (300+ rounds per session), so I break it down anyway, no matter what the old timers at the range tell me.