I just went through this.
The p22s we had at the NRA Basic Pistol Course were jamming during the class. I’ve read similar complaints about the Mosquito, SR22, the 22lr conversions, and other semi autos with slides on forums. They’re ammunition fussy, maybe not the S&W 22LR or other high end target pistols.
I’m guessing the semi-auto design with moving slide & barrel have too much mass for the 22LR to reliably move each time. I say this because I don’t remember reading any complaints about jamming on the Rugar Mk I, II, & IIIs, Black Hawks or other fixed barrel semi-autos that only have a bolt to move. The comments on these I’ve read are that they cycle any 22lr ammo you put in them.
I’ve a Ruger Mk III 22/45 now and it hasn’t jammed on me once, but I haven’t really put a lot of rounds through it yet. I’m a believer in ‘mature’ designs. The grip does feel skinny, but then my other pistol is a Glock.
"Sometimes I pretend to be normal, but it's boring and I go back to being me."
"You might as well be yourself, people wont like you anyway."