Let me preface this with: I'm 6'6", 250lbs. I have BIG hands. BIG hands. I think the P22 might be slightly too small, but it's VERY comfortable to shoot. It really is incredible how comfortable that gun can be. Have you ever held one? Pick one up, point it around, set it down, pick it up again. You get used to it quickly. My girlfriend is 5'8" and otherwise petite, and it fits her as well. I own a P22 and have 4654 rounds through it. I get the occasional FTE/FTF, but most of the FTF's have been the ammo's fault. Most of the FTE's start occurring after 300 rounds at the range of the cheap bulk stuff. I shot 700 rounds of CCI MiniMag the first day at the range and didn't have the slightest of problems. I was looking for a centerfire pistol-style 22LR pistol to train my girlfriend on (and get her used to pistols as she was afraid of them). I couldn't be happier. I definitely like it better than the Sig Mosquito. I now want a 1911-22 (not instead of, but as well as, my P22) since I recently bought a 1911, but I learned a lot from shooting the P22.
The other thing I'd recommend is looking through this list
. It might help.