Love all my handguns, but my favorite has to be the Colt Python. But I also have a Diamondback that is just as sweet. Really like my Colt Woodsman Match Target and Smith and Wesson Model 41 as well. It's hard to pick, like Jon sort of eluded to above, it kind of depends on the day and what you're currently shooting.
"I ask sir, what is the militia? It is the whole people except for a few politicians."
- George Mason (father of the Bill of Rights and The Virginia Declaration of Rights)