This might be of interest for your wife...
Charter Southpaw #93820
I have always loved the simplicity of a revolver, Ruger GP100/SP101 in paticular...... but decided to try out Charter's Southpaw for myself. It has cut reload time in half on average, because of where the cylinder release is located, and the direction of where the cylinder opens towards. ( Exact opposite of your average wheel gun.) The grip angle/feel is very much like a Rossi 38 that I own, only less weight overall due to the Aluminum 7075 frame.
So....unless Ruger comes ount with lefty versions of the GP-100/SP101, my new favorite wheel gun is this one.
As for semiauto's......my favorite flavor has been the Glock-19 (no brass in my face with them either. I tap the mag realease using left index finger, and rack the slide, skipping the slide release altogether.
That is until the summer before last. ( Found a Springfield Armory XD40 service at 125 even, and have been happy with it ever since). It just feels better in my 'left mitt', and I shoot fairly decent with the thing. The ambi mag release is convenient for me as it took me awhile to 're-train' myself to use it with the left thumb vs left index finger. No brass at the mug with the XD either. Currently eyeballin the XDM with interest as of late.
For what it's worth, the only time I had brass hit me was while shooting an ole worn out M9 at work. Only happened with this gun in paticular.