Originally Posted by bayouBore
I'd rather Swiss cheese a bucket that put one or two holes "big holes".
You get quicker volume loss through multiple cavities in the bucket, as opposed to taking the same amount of time to make just 1 or 2 large holes.
Minimizing muzzle flip is extremely beneficial to shot placement under high stress, especially when your life is in danger and adrenaline can cause you to make more imprecise shots than you would've ever performed normally in practice.
When you have the ability to shoot more bullets than the big bores in the same brief period of time, you get a larger acceptable window of error with less time between your target acquisition (and the added bonus of extra ammo capacity).
FWIW, I have a .45 KRISS Vector as my go-to home defense weapon. The low recoil design of this gun makes the .45 preferable to me, and the stopping power may be needed for the pain-resistant junkies that tend to break into homes. For daily carry, I switch between any of my 9mm handguns or my 4" Chiappa Rhino chambered with 38 Specials.
Like many have said already, shoot what shoots best for you and not for someone else. It's always important to consider personal requirements & biases as everyone is different.