I carry an AMT S/A Backup in .380, and after reviewing penetration stats, don't carry anything other than 95gr FMJ. My take on it is that you have to get to the giblets to make it count, and I don't have confidence that HP's are going to do the job. Not dissing the Hornady's, as that's what I carry in 9mm, and there again based on looking at the stats. With a 2" barrel, I'll start keyholing at about 35' with the .380, which takes any benefit from an HP round out of the equation at a relatively short range. In closer, first one to the medulla oblongata wins.