Do you have source of .22 ammo? All the great choices of guns won't mean diddly if you can't locate ammo for them.
If your wife is going to carry, you might do well to get her something that is similar in function to her carry gun.
A coworker recently ordered a .22 version of the Bersa Thunder. He carries the .380 version.
Food for thought anyway.
For just a plain old plinker/paper puncher, you will find the Ruger Mk3 or 22/45 hard to beat, both for price and quality. The blued ones are a screaming bargain.
MSgt, USAF, Retired
NRA Life Member
The hardest thing to explain is the glaringly evident which everybody had decided not to see. - Ayn Rand